3 edition of ADP-ribosylation, DNA repair, and cancer found in the catalog.
ADP-ribosylation, DNA repair, and cancer
Takamatsu no Miya Hi Gan KenkyЕ« Kikin. (13th 1982 Tokyo, Japan)
Includes bibliographies and indexes.
|Statement||edited by Masanao Miwa ... [et al.].|
|Series||Princess Takamatsu symposia -- 13|
|LC Classifications||RC268.5 T34 1982|
|The Physical Object|
|Pagination||xvi, 338 p. :|
|Number of Pages||338|
|ISBN 10||4762263770, 9067640034|
ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which controls major cellular and biological processes, including DNA damage repair, cell proliferation and differentiation, metabolism, stress and immune responses. ADP-Ribosylation and Regulation of DSBR. DNA DSBs can be repaired by homologous recombination (HR) or non-homologous end joining (NHEJ). 31 HR uses sequences homologous to the damaged DNA template to facilitate repair in late S and G 2 phases of the cell cycle. The initiating step of HR is 5′-3′ resection of DNA termini by multiple nuclease activities. 32 Mediators promote formation of .
This volume reflects the widespread interest in ADP-ribosylation and presents current research in four areas: molecular biology of poly (ADP-ribose) polymerase; cancer, DNA repair . During this process, ADP-ribosylation of chromatin leads to chromatin reorganization, recruitment of the DNA repair machinery, and regulation of gene expression (Tallis et al., ). It is noteworthy that ADP-ribosylation also occurs in the absence of DNA damage, suggesting a broad function of this PTM in physiological and pathological conditions.
ADP-ribosylation: a DNA break signal mechanism --Measurement of poly(ADP-ribose)glycohydrolase activity by high resolution polyarcylamide gel electrophoresis: specific inhibition by histones and nuclear matrix proteins --Regulatory mechanisms of poly(ADP-ribose)polymerase --Poly(ADP-ribose)polymerase: a guardian of the genome that facilitates. ADP-ribosylation is a posttranslational modification of proteins that involves the addition of one or more ADP and ribose moieties.. These reactions are involved in cell signaling and the control of many cell processes, including DNA repair and apoptosis.
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ADP-ribosylation, DNA and cancer book, cell differentiation and cancer. Shall S. This review discusses the potential relationships between ADP-ribosylation reactions, DNA repair, cell differentiation, and cancer. ADP-ribosylation of chromatin proteins has been shown to participate in ADP-ribosylation excision repair Cited by: ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein.
It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis.
Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as cholera. Zdenko Herceg, Rabih Murr, in Handbook of Epigenetics, ADP-ribosylation.
ADP-ribosylation is a post-translational modification defined by the addition of an ADP-ribose moiety onto a protein using NAD+ as a substrate. If the transfer takes place on an amino-acid acceptor, it is referred to as mono- or poly-(ADP-ribosyl)ation (PARation) and if it occurs on an acetyl group it is called O.
Get this from a library. ADP-ribosylation, DNA repair, and cancer: proceedings of the 13th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, [Masanao Miwa; Takamatsu no Miya Hi Gan Kenkyū Kikin. International Symposium]. Proceedings of the International Symposia of the Princess Takamatsu Cancer Research Fund, Volume 13 ADP-Ribosylation, DNA Repair and Cancer.
DOI link for Proceedings of the International Symposia of the Princess Takamatsu Cancer Research Fund, Volume 13 ADP-Ribosylation, DNA Repair and CancerAuthor: Takashi Sugimura, Miwa, Hayaishi, Shall, Smulson.
Keywords:ADP-ribosylation, cancer, chromatin, DNA repair, gene transcription, macrodomains, neurodegeneration, PARPs, signaling. Abstract:ADP-ribosylation describes an ancient and highly conserved posttranslational modification (PTM) of proteins.
Many cellular processes have been identified that are regulated by ADP-ribosylation, including DNA. Poly(ADP-ribosyl)ation (aka PARylation) is a unique protein post-translational modification (PTM) first described over 50 years ago.
PARylation regulates a number of biological processes including chromatin remodeling, the DNA damage response (DDR), transcription, apoptosis, and mitosis. The anti-cancer drug target poly(ADP-ribose) polymerase 1 (PARP1) and its close homologue, PARP2, are early responders to DNA damage.
The role of ADP-ribosylation in promoting protein aggregation in diseases such as ALS, FTD, and PD is a more recent concept. Many of the disease pathways linked in ALS/FTD (reviewed in) are regulated by ADP-ribosylation, including (i) DNA damage, (ii) protein localization, (iii) protein aggregation, and (iv) cell death.
These include signal transduction mechanisms, stress pathways associated with the endoplasmic reticulum and stress granules, and chromatin-associated processes such as transcription and DNA repair. We hypothesize that mono-ADP-ribosylation controls, through these different pathways, the development of cancer and infectious diseases.
Introduction. BRCA1 is a breast and ovarian cancer- suppressing gene and a major contributor to genome integrity control. The latter function is a major component of its tumor suppressing function (1, 2).Among its various DNA damage response functions, BRCA1 normally promotes error-free, homologous recombination-type, DNA damage repair (HRR).
ADP-ribosylation and the repair of ‘indirect’ SSBs, during base excision repair In contrast to ‘direct’ SSBs, such as those induced by disintegration of deoxyribose, it is less obvious why a ‘sensor’ role for PARP-1 might have utility at SSBs arising during DNA base excision repair (BER).
Recent Advances, Future Prospects. The field of PARPs and ADP-ribosylation has experienced a sea change over the past two decades. The focus of the field has shifted dramatically during this time, from DNA repair under stress conditions to regulation of gene expression, RNA, and cytoplasmic functions under normal physiological conditions.
Poly-ADP ribosylation in DNA damage response and cancer therapy Article (PDF Available) in Mutation Research/Reviews in Mutation Research. Miwa M, Hayaishi O, Shall S, Smulson M, Sugimura T (eds) () ADP-ribosylation, DNA repair and cancer. Jpn Sci Soc Press, Tokyo/VNU Science Press, BV, Utrecht Google Scholar 2.
ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a well-established role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium to uncover a role for ADP-ribosylation in regulating DNA interstrand crosslink repair and redundancy of this pathway with non-homologous end.
Buy Physical Book Learn about institutional subscriptions. Papers Table of contents (74 papers Cancer, DNA Repair, and Metabolism. Front Matter. ADP-Ribosylation is Involved in the Integration of Exogenous DNA into the Mammalian Cell Genome, but is not Required for the Episomal Replication or Expression of Autonomously Replicating.
Shall S () ADP-ribosylation, DNA repair, cell differentiation and cancer. In: Miwa M, Hayaishi O, Shall S, Smulson N, Sugimura T (eds) ADP-ribosylation, DNA repair and cancer. VNU Sci Press, Utrecht, p 3 Google Scholar. The Seventh International Symposium on ADP-Ribosylation Reac tions was only possible because of the generous support which we have been given by our sponsors, listed below.
Keywords Calcium DNA Nucleotide cancer cell cell culture cell death cellular differentiation enzyme enzymes gene expression metabolism mutation protein transcription. The DNA damage-induced poly(ADP-ribosyl)ation is mainly catalyzed by PARP1, 2 and 3, although 17 PARPs have been identified on the basis of homologous information to the funding member PARP1.
Most published work on post-translational histone modifications focuses on small covalent alterations such as acetylation, methylation and phosphorylation. By contrast, fewer data are available on the modification of histones by ADP-ribose. Discussion of the biological significance of histone ADP-ribosylation has often been restricted to functions of the modifying enzymes, rather than to.
Deficiencies in DNA repair appear to be central to the genomic and epigenomic instability characteristic of cancer. Figure 3 illustrates the chain of consequences of exposure of cells to endogenous and exogenous DNA damaging agents that lead to cancer. The role of germ line defects in DNA repair genes in familial cancer are also indicated.DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.
Experts on DNA repair proteins from all areas of cancer biology research take readers from.